ASSOCIATION STUDY BETWEEN VITAMIN D RECEPTOR GENE APAI POLYMORPHISM AND OSTEOPOROSIS IN POPULATION OF LAHORE
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Author:
RIFAT SHAFI
Citable URI :
https://vspace.vu.edu.pk/detail.aspx?id=341
Publisher :
Virtual University
Date Issued:
7/4/2020 12:00:00 AM
Abstract
Osteoporosis is known as a chronic and systemic bone disorders. Osteoporosis
xiv
destroys the bone microarchitecture tissues thus bone becomes so weak that leads the high
risk of fractures. Mostly women are affected than men. Osteoporosis and its related fractures
has become serious problem in Pakistani elder population and according to survey the
prevalence of osteoporosis in our country is 9.9 million and 7.2 million out of them are
osteoporotic women. Genes of Vitamin D receptor (VDR) consider as candidate gene for bone
mass regulation in osteoporosis. The current study examined the VDR gene polymorphism
(ApaI) on PCR-RFLP based on hundred samples among the population of Lahore, city of
Pakistan to determine prevalence of osteoporosis and compare the frequency of osteoporosis
between genotype and allelic sub-groups. The analysis showed that the single nucleotide
polymorphism (SNP) followed HardyWeinberg equilibrium (HWE) that p > 0.05. No
significant association was found among case and controls for allelic and genotypic
frequency. The case and controls both have almost same frequency of AA, AC and CC
genotype. Almost same allelic (A and C) frequency of ApaI also demonstrated no significant
association among case and controls. Therefore it was observed that ApaI polymorphic site on
VDR gene has no significance relation for osteoporosis in studied patients (p> 0.05). The
current study recommended that ApaI VDR genotype could not be candidate gene leading to
osteoporosis. The current study is also tried to uncover its associated risk factors that
Phosphorus has significance association (p =.006) with normal and patient (by an
independent-sample t-test) hence it has also significant association (p =.026) with age groups
(by ANOVA). It means that phosphorus has key function for bones development and bone
strength
URI :
https://vspace.vu.edu.pk/details.aspx?id=341
Citation:
Shafi, R(2019),ASSOCIATION STUDY BETWEEN VITAMIN D RECEPTOR GENE APAI POLYMORPHISM AND OSTEOPOROSIS IN POPULATION OF LAHORE,VIRTUAL UNIVERSITY OF LAHORE.(Lahore,Pakistan).
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Final Version
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