Association analysis of AR gene polymorphism with androgenetic alopecia
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Author:
SADIA KOUSAR
Citable URI :
https://vspace.vu.edu.pk/detail.aspx?id=237
Publisher :
Virtual University
Date Issued:
8/20/2019 12:00:00 AM
Abstract
Alopecia is a genetic disorder characterized by distinct forms of baldness. Main reason of alopecia is the imbalance between hair fall and regrowth. Alopecia has two broad types syndromic alopecia which occur along with other clinical conditions like epilepsy, nail dystrophy etc. Non syndromic alopecia does not show any extra clinical conditions. Androgenetic alopecia is commonly known as male pattern baldness. 80% of males above age of 70s and 80s are affected by this condition. In Asian general population approximately 73% instances of disorder has been reported. High level of circulating androgens which are actually steroid hormones are possible cause of male pattern baldness as scalp hair follicles show sensitivity for these circulating androgens. This association between androgens and male pattern baldness make androgen receptor gene as a promising candidate to check the pathogeneses of androgenetic alopecia. The rs6152 a single nucleotide polymorphism in exon 1 of AR gene has been reported in association with androgenetic alopecia. This study will check the association of mention polymorphism with AGA in random Pakistani male population.
URI :
https://vspace.vu.edu.pk/details.aspx?id=237
Citation:
Kousar, S(2018). Association analysis of AR gene polymorphism with androgenetic alopecia. Virtual University of Pakistan.(Lahore, Pakistan).
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Final Version
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