Browse

The Virtual University, Pakistan’s first University based completely on modern Information and Communication Technologies, was established by the Government as a public sector, not-for-profit institution with a clear mission: to provide extremely affordable world class education to aspiring students all over the country.

Using free-to-air satellite television broadcasts and the Internet, the Virtual University allows students to follow its rigorous programs regardless of their physical locations. It thus aims at alleviating the lack of capacity in the existing universities while simultaneously tackling the acute shortage of qualified professors in the country. By identifying the top Professors of the country, regardless of their institutional affiliations, and requesting them to develop and deliver hand-crafted courses, the Virtual University aims at providing the very best courses to not only its own students but also to students of all other universities in the country.

STUDY OF GENETIC MUTATION RESPONSIBLE FOR MULTI DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATES OF AZAD JAMMU AND KASHMIR

Download

Author: FARAH NAZ


Citable URI : https://vspace.vu.edu.pk/detail.aspx?id=219

Publisher : Virtual University

Date Issued: 7/23/2019 12:00:00 AM


Abstract

Tuberculosis (TB) is an airborne disease caused by bacterium Mycobacterium tuberculosis. TB is one of the ever- growing health problems across the globe. Its control has been hindered by the emergence of drug resistance developed by the bacterium against key drugs used for treatment of the disease. The objective of the current study was to analyze the genetics and epidemiology of multi drug resistant tuberculosis in Azad Jammu & Kashmir. A total of 69 samples from tuberculosis suspects were screened for M. tuberculosis strains through sputum smear microscopy using Ziehl-Neelsen staining. All of the samples, either positive or negative in the smear microscopy, were checked for drug resistance by performing Xpert MTB/RIF assay. Study results showed a total of 32 samples (46.38%) were positive for M. tuberculosis in smear microcopy, whereas 56 out of 69 (81.15%) samples appeared positive in Xpert MTB/RIF assay, which establishes the authenticity of Gene Xpert assay over smear microscopy. Xpert MTB/RIF assay revealed that 4 out of 56 positive samples exhibited mutations in rpoB gene. Occurrence of tuberculosis in this study was higher in males (55.07%) than females (44.93%). The majority of the tuberculosis cases were aged between 11 to 30 years (46.38%). The medical history including incidence of adverse drug reactions during the treatment of the tuberculosis suspects were also examined. Epidemiology of MDR-TB indicated that Muzaffarabad had higher prevalence of MDR-TB than other areas of Azad Jammu & Kashmir. The unsatisfactory knowledge of Participants about MDR-TB and its diagnostics is critical highlights the dire need to develop educational programs for MDR-TB awareness in community along with treatment and prevention of this deadly menace.


URI : https://vspace.vu.edu.pk/details.aspx?id=219

Citation: Naz, F,(2018), STUDY OF GENETIC MUTATION RESPONSIBLE FOR MULTI DRUG RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS ISOLATES OF AZAD JAMMU AND KASHMIR. Virtual University of Pakistan.(Lahore, Pakistan).

Version : FInal Version

Terms of Use :

Detailed Terms :

Journal :

Files in this item

Name Size Format
Fall 2018_BT720_ms150400844.pdf 589kb pdf


Copyright 2016 © Virtual University of Pakistan