Browse

The Virtual University, Pakistan’s first University based completely on modern Information and Communication Technologies, was established by the Government as a public sector, not-for-profit institution with a clear mission: to provide extremely affordable world class education to aspiring students all over the country.

Using free-to-air satellite television broadcasts and the Internet, the Virtual University allows students to follow its rigorous programs regardless of their physical locations. It thus aims at alleviating the lack of capacity in the existing universities while simultaneously tackling the acute shortage of qualified professors in the country. By identifying the top Professors of the country, regardless of their institutional affiliations, and requesting them to develop and deliver hand-crafted courses, the Virtual University aims at providing the very best courses to not only its own students but also to students of all other universities in the country.

Toxic effects of pregabalin and its derivatives on liver and kidney by using rat model

Download

Author: SADIA RIASAT ALI


Citable URI : https://vspace.vu.edu.pk/detail.aspx?id=151

Publisher : Virtual University

Date Issued: 11/7/2018 12:00:00 AM


Abstract

Drugs contain the different component with different dosage concentration and some of them cause the toxicity in liver and kidney. In current study, male wistar rats were divided into three groups and kept in the animal house of the University of Health Sciences Lahore under standard conditions. Group I was serve as control while Group II and III had given by benzaldehyde and salicyldehyde derivative of pregabalin for 28 days, respectively. The behavioral changes, body weight and eating habits were remained same in all groups. There was not mortality rate occur in all groups. After sacrificing the animals, it was observed that there is not morphological and gross change in the color and texture of the liver and kidney. Hematological analysis has not showed the any significant difference in leukocyte count and MCV, platelet count, hemoglobin concentration (Hb), packed cell volume (PCV), erythrocyte count, mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). Biochemical analysis showed the elevation in AST and creatinine while the vales of bilirubin, BUN and ALT remain normal.


URI : https://vspace.vu.edu.pk/details.aspx?id=151

Citation: Ali, S.A(2018), Toxic effects of pregabalin and its derivatives on liver and kidney by using rat model. Virtual University of Pakistan.(Lahore, Pakistan).

Version : Final Version

Terms of Use :

Detailed Terms :

Journal :

Files in this item

Name Size Format
Spring 2018_ZOO720_MS160200220.pdf 1230kb pdf


Copyright 2016 © Virtual University of Pakistan