HEPATOPROTECTIVE EFFECTS OF ARABICA COFFEE BEANS IN PARACETAMOL INDUCED HEPATOTOXIC ANIMAL MODELS
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Author:
FATIMA SADIQ
Citable URI :
https://vspace.vu.edu.pk/detail.aspx?id=149
Publisher :
Virtual University
Date Issued:
11/7/2018 12:00:00 AM
Abstract
Liver is a vital body organ and has an important role in various body functions. However, it is
susceptible to a number of diseases due to pathogenic microorganisms, toxins and other harmful
agents. The management of liver diseases is difficult with conventional medicines so there is an
increased interest in alternative medicines for improving liver function. Coffee is a commonly
consumed beverage and it is found to exert beneficial effects on a body. In this study, the
hepatoprotective effects of Arabica coffee beans in paracetamol (PCM)-induced liver injury
animal models were determined. Rabbits were randomly divided into three groups. The liver
injury model was generated by oral ingestion of PCM at a dose of 1g/kg/body weight of each
animal. To evaluate the preventive effects of coffee, the third group received a co–treatment of
PCM and coffee. Hepatoprotective effects of coffee were evaluated by testing the parameters of
liver functioning enzymes, lipid profile and renal efficiency assays. PCM reduced the levels of the markers of the liver injury. It also reduced the harmful parameters of lipid profile. However
there was no significant change in comparison to control. In conclusion, coffee was found to
prevent the liver deteriorating effects of PCM along with the restoration of lipid profile in
hepatoxicity induced rabbits.
URI :
https://vspace.vu.edu.pk/details.aspx?id=149
Citation:
Sadiq, F(2018). HEPATOPROTECTIVE EFFECTS OF ARABICA COFFEE BEANS IN PARACETAMOL INDUCED HEPATOTOXIC ANIMAL MODELS. Virtual University of Pakistan.(Lahore, Pakistan).
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Final Version
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