ANTIBACTERIAL ACTIVITY THROUGH CEFDITOREN DERIVED FROM SILVER NANOPARTICLES AGAINST GRAM POSITIVE BACTERIA
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Author:
GHULAM MOHYYODIN QUMAR
Citable URI :
https://vspace.vu.edu.pk/detail.aspx?id=125
Publisher :
Virtual University
Date Issued:
6/7/2018 12:00:00 AM
Abstract
Antibacterial substances may be synthetic, semi-synthetic or derived from
natural materials. They were recognized as miracle drugs if they had strong
effectiveness against harmful microorganisms and were recovered suffering patients
as soon as possible. However, they become multiple resistant to pathogens if they
were used improperly. This multidrug resistant problem had become a major
challenge for global healthcare practitioners. The major cause of this problem was the
continuous spreading of drug resistant bacteria by different processes. So to overcome
such problems some new methods had been developed. These methodologies had
replaced conventional antibiotics to control the multiple drug resistance. Among these
technologies one of them is the green synthesis of cefditoren derived silver nano
particles (AgNPs). They were synthesized via a simple one-pot method after mixing
AgNO 3 and cefditoren in NaOH aqueous solution. These synthesized nanoparticles
were characterized by UV-Visible Spectroscopy and Fourier transform Infrared (FT-
IR) spectroscopy. Cefditoren and synthesized AgNPs solutions were tested against
three-gram positive bacterial species like Streptococcus pneumoniae, Streptococcus
pyogenes and Staphylococcus aureus. The data revealed that cefditoren showed little
inhibition against all tested bacterial species while cefditoren derived AgNPs showed
maximum activities against all these three bacteria. These activities were dose
dependent when compared to cefditoren. These findings could pave the way for
finding the changing behavior associated with other antibiotics after capping AgNPs
or other metal nano particles and may be used against other resistant strains.
URI :
https://vspace.vu.edu.pk/details.aspx?id=125
Citation:
Qumar, G.M,(2017), ANTIBACTERIAL ACTIVITY THROUGH CEFDITOREN DERIVED FROM SILVER NANOPARTICLES AGAINST GRAM POSITIVE BACTERIA. Virtual University of Pakistan.(Lahore, Pakistan)
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Final Version
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