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The Virtual University, Pakistan’s first University based completely on modern Information and Communication Technologies, was established by the Government as a public sector, not-for-profit institution with a clear mission: to provide extremely affordable world class education to aspiring students all over the country.

Using free-to-air satellite television broadcasts and the Internet, the Virtual University allows students to follow its rigorous programs regardless of their physical locations. It thus aims at alleviating the lack of capacity in the existing universities while simultaneously tackling the acute shortage of qualified professors in the country. By identifying the top Professors of the country, regardless of their institutional affiliations, and requesting them to develop and deliver hand-crafted courses, the Virtual University aims at providing the very best courses to not only its own students but also to students of all other universities in the country.

ANTIBACTERIAL ACTIVITY THROUGH CEFDITOREN DERIVED FROM SILVER NANOPARTICLES AGAINST GRAM POSITIVE BACTERIA

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Author: GHULAM MOHYYODIN QUMAR


Citable URI : https://vspace.vu.edu.pk/detail.aspx?id=125

Publisher : Virtual University

Date Issued: 6/7/2018 12:00:00 AM


Abstract

Antibacterial substances may be synthetic, semi-synthetic or derived from natural materials. They were recognized as miracle drugs if they had strong effectiveness against harmful microorganisms and were recovered suffering patients as soon as possible. However, they become multiple resistant to pathogens if they were used improperly. This multidrug resistant problem had become a major challenge for global healthcare practitioners. The major cause of this problem was the continuous spreading of drug resistant bacteria by different processes. So to overcome such problems some new methods had been developed. These methodologies had replaced conventional antibiotics to control the multiple drug resistance. Among these technologies one of them is the green synthesis of cefditoren derived silver nano particles (AgNPs). They were synthesized via a simple one-pot method after mixing AgNO 3 and cefditoren in NaOH aqueous solution. These synthesized nanoparticles were characterized by UV-Visible Spectroscopy and Fourier transform Infrared (FT- IR) spectroscopy. Cefditoren and synthesized AgNPs solutions were tested against three-gram positive bacterial species like Streptococcus pneumoniae, Streptococcus pyogenes and Staphylococcus aureus. The data revealed that cefditoren showed little inhibition against all tested bacterial species while cefditoren derived AgNPs showed maximum activities against all these three bacteria. These activities were dose dependent when compared to cefditoren. These findings could pave the way for finding the changing behavior associated with other antibiotics after capping AgNPs or other metal nano particles and may be used against other resistant strains.


URI : https://vspace.vu.edu.pk/details.aspx?id=125

Citation: Qumar, G.M,(2017), ANTIBACTERIAL ACTIVITY THROUGH CEFDITOREN DERIVED FROM SILVER NANOPARTICLES AGAINST GRAM POSITIVE BACTERIA. Virtual University of Pakistan.(Lahore, Pakistan)

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